all publications
DHA acid and human brain development: Evidence that a dietary supply is needed for optimal development
Brenna JT. et al, DHA and human brain development: evidence that a dietary supply is needed for optimal development. (2014) J. Hum. Evol. 77:99
Applications of Deuterium in medicinal chemistry
Pirali T, et al. Applications of Deuterium in medicinal chemistry. (2019) J.Med.Chem. 62:5276
Plasma and RBC cell membrane accretion and PK of RT001
Brenna TJ. et al. Plasma and RBC cell membrane accretion and PK of RT001 (bis-allylic 11,11-D2-linoleic acid ethyl ester) during long term dosing in patients. (2020) J. Pharm. Sci.
Free Radicals in Biology and Medicine
Halliwell B. et al. Free Radicals in Biology and Medicine, (2015) Oxford University Press.
Deuterated docosahexaenoic acid protects against oxidative stress and geographic atrophy-like retinal degeneration in a mouse model with iron overload
Liu et al. Deuterated docosahexaenoic acid protects against oxidative stress and geographic atrophy-like retinal degeneration in a mouse model with iron overload. Aging Cell. 2022
Isotope-reinforced PUFAs protect yeast cells from oxidative stress
Hill S. et al. Isotope-reinforced PUFAs protect yeast cells from oxidative stress. (2011) Free Rad. Biol. Med. 50:130(2019) J.Med.Chem. 62:5276
Peroxidation of PUFAs by lipoxygenases drives ferroptosis
Yang WS. et al. Peroxidation of PUFAs by lipoxygenases drives ferroptosis. (2016) Proc. Natl. Acad. Sci. USA doi/10.1073/pnas.1603244113
Isotopic reinforcement of essential PUFAs diminishes nigrostriatal degeneration in a mouse model of Parkinson’s disease
Shchepinov MS. et al. Isotopic reinforcement of essential PUFAs diminishes nigrostriatal degeneration in a mouse model of Parkinson’s disease. (2011) Tox. Letters 207:97.
Deuterium-reinforced PUFAs protect against atherosclerosis by lowering lipid peroxidation and hypercholesterolemia
Berbee JFP. et al. Deuterium-reinforced PUFAs protect against atherosclerosis by lowering lipid peroxidation and hypercholesterolemia. (2017) Atherosclerosis 264:100.
PUFA deuteration against neurodegeneration
Shchepinov MS. PUFA deuteration against neurodegeneration. (2020) Trends Pharmacol. Sci. 41:236.
D-PUFAs reduce brain lipid peroxidation and hippocampal amyloid beta-peptide levels
Raefsky SM. et al. D-PUFAs reduce brain lipid peroxidation and hippocampal amyloid beta-peptide levels, without discernible behavioural effects in an APP/PS1 mutant transgenic mous
Deuterium-reinforced PUFAs improve cognition in a mouse model of sporadic Alzheimer’s disease
Elharram A. et al. Deuterium-reinforced PUFAs improve cognition in a mouse model of sporadic Alzheimer’s disease. (2017) FEBS J. 284:4083
